Synthesis of 4′-aza analogues of 2′,3′-dideoxythymidine by 1,3-dipolar cycloadditions of nitrones to 1-N-vinyl-thymine

Article abstract of DOI:10.1016/0040-4039(95)02373-9

The title compounds have been obtained by 1,3-dipolar cycloadditions of methylene nitrones, prepared in situ from suitably protected hydroxylamines, to 1-N-vinyl-thymine. The 4′-aza-2′,3′-dideoxyerythrofuranoside (4), an analogue of 2′,3′-dideoxythymidine