H-phosphonate DNA synthesis without amino protection

DOI: 10.1016/S0040-4039(00)61075-4

Source and publish data:

Tetrahedron Letters p. 5869 - 5872 (1992)

Update date:2022-08-03

Topics:

Authors:

Kung Kung

Jones Jones

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Article abstract of DOI:10.1016/S0040-4039(00)61075-4

DNA synthesis by the H-phosphonate method does not require the use of amino protecting groups. The cytosine amino group, and the guanine O6/N1 positions, do react with the condensing agent to some extent, but these derivatives are cleaved under the standa

Full text of DOI:10.1016/S0040-4039(00)61075-4

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