New applications of the Mitsunobu reaction in the synthesis of C-2 N-methyl carbapenems

DOI: 10.1016/S0040-4039(00)60855-9

Source and publish data:

Tetrahedron Letters p. 7133 - 7136 (1992)

Update date:2022-09-26

Topics:

Authors:

Arnould Arnould

Landier Landier

Pasquet Pasquet

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Article abstract of DOI:10.1016/S0040-4039(00)60855-9

N-acyl amides and N-acylamino heterocycles can be reacted regioselectively with C-2 hydroxymethyl carbapenems under Mitsunobu conditions:synthesis of amides, exocyclic alkylation of amino heterocycles and transformation into 2-aminomethyl carbapenems are

Full text of DOI:10.1016/S0040-4039(00)60855-9

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