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The Synthesis of C3-Methyl, C3-Decarboxy-Zaragozic Acid A. A Potent Squalene Synthase Inhibitor

DOI: 10.1016/S0040-4039(00)91815-X

Source and publish data:

Tetrahedron Letters p. 6863 - 6866 (1993)

Update date:2022-08-04

Topics:

Authors:

Kuo, C. H.Kuo, C. H.

Plevyak, S. P.Plevyak, S. P.

Biftu, T.Biftu, T.

Parsons, W. H.Parsons, W. H.

Berger, G. D.Berger, G. D.

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Article abstract of DOI:10.1016/S0040-4039(00)91815-X

The title compound and its C4-pivaloyloxy methyl (POM) ester have been synthesized by converting zaragozic acid A to the key intermediate of the protected C3-hydroxymethyl compound 6.Subsequent radical deoxygenation via the Barton-McCombie procedure, foll

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Full text of DOI:10.1016/S0040-4039(00)91815-X

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