Journal of Medicinal Chemistry p. 151 - 157 (1991)
Update date:2022-09-26
Topics:
Bradbury, Robert H.
Rivett, Janet E.
Two series of 1,2,4-triazolo<4,3-a>pyrazine derivatives with human renin inhibitory activity have been synthesized which incorporate the transition-state mimetics (3S,4S)- and (3R,4S)-5-cyclohexyl-3,4-diaminopentanoic acid ((S)- and (R)-CDAPA), and (4S)-4
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