1,2,4-Triazolopyrazine Derivatives with Human Renin Inhibitory Activity. 3. Synthesis and Biological Properties of Aminodeoxystatine and Difluorostatone Derivatives

Article abstract of DOI:10.1021/jm00105a022

Two series of 1,2,4-triazolo<4,3-a>pyrazine derivatives with human renin inhibitory activity have been synthesized which incorporate the transition-state mimetics (3S,4S)- and (3R,4S)-5-cyclohexyl-3,4-diaminopentanoic acid ((S)- and (R)-CDAPA), and (4S)-4