Chemical and Pharmaceutical Bulletin p. 1439 - 1446 (1997)
Update date:2022-08-05
Topics:
Oda, Kozo
Yoshida, Akira
S[2(Dialkylaminocarbonyl)phenyl](2R)2[(3S,4S)3[(1R)1(tertbutyldimethylsilylox y)ethyl)]2oxo4azetidinyl]thiopropionate (11), useful intermediates for the synthesis of 1β-methylcarbapenems including 1β-methylthienamycin, were prepared in a highly stereoselective manner by the reaction of E-1-(tert- butyldimethyl-silyloxy)-1-[2-(dialkylaminocarbonyl)phenylthio]-1-propene (10) with commercially available (3S,4R)-3-[(1R)-1-(tert- butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one (6) in the presence of zinc chloride catalyst. The diethylaminocarbonyl derivative (11b) was particularly convenient for practical production because of its highly crystalline nature.
View MoreHubei Onward Bio-Development Co., Ltd.
Contact:+86-718-8417012
Address:No.517,Shizhou Avenue,Enshi City,Hubei Province,China,445002
Contact:+86-15850770348
Address:51 OF XIANGFANGCUN ROAD, Nanjing 210002, China
Nanjing Legend Pharmaceutical & Chemical Co., Ltd.
Contact:+86-25-83767696
Address:14-7 Zhongshan Lu Guluo District, Nanjing
website:http://www.china-sinoway.com
Contact:+86-592-5853819
Address:16/F,Huicheng Comm,Complex,No839 XiaHe Rd, Xiamen,China
Jinan Jiaquan Chemical Co.,Ltd
Contact:+86-531-62318366
Address:Room 502 of Yidonghuayuan No.601 Huaxin Road Licheng District Jinan China
Doi:10.1081/SIM-100105259
(2001)Doi:10.7164/antibiotics.30.141
(1977)Doi:10.1039/P19720002548
(1972)Doi:10.1007/BF00944232
()Doi:10.1021/jo00956a017
(1973)Doi:10.1021/jo00958a004
(1973)
