Tetrahedron p. 10103 - 10114 (1992)
Update date:2022-07-27
Topics:
Monteiro, Nuno
Gore, Jacques
Balme, Genevieve
In the presence of a palladium(0) complex and potassium t-butoxide, the acetylenic compounds 2 bearing in δ a nucleophilic functionality are smoothly transformed with excellent yields, either into 2,2-difunctionalized methylene cyclopentanes or into monofunctionalized 2-methylcyclopentenes. Each of these compounds can be specifically obtained depending on the choice of the experimental conditions. A set of diverse reactions involving mainly potassium hydride as the base showed clearly that HPdOtBu is not the active catalytic species which is mainly a σ-ethynylpalladium hydride formed by the metal insertion in the acetylenic carbon hydrogen bond.
website:http://www.konochem.com
Contact:86-29-86107037
Address:No.170 West Avenue,Xi’an 710082,China
Changzhou Anyi Biochem Co., Ltd.(expird)
Contact:+86-519-88836158
Address:no,51 caoda
Chuzhou Baiao Biologhy S&T Co., Ltd.
Contact:+86-25-83212599；+86-25-83212699 13705185959
Address:Room 905, Tianzheng International Platza, No.399, Zhongyang Road ,Nanjing, Jiangsu Province, China
website:http://www.simagchem.com
Contact:+86-592-2680277
Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China
Quzhou Aokai Chemical Co., Ltd.
Contact:86-570-3032832
Address:NO.16 , Laodong Road,Quzhou City, Zhejiang Province,China
Doi:10.1021/acs.orglett.0c03723
(2021)Doi:10.1055/s-0033-1339346
(2013)Doi:10.1002/cmdc.201700271
(2017)Doi:10.1248/cpb.38.562
(1990)Doi:10.1016/S0960-894X(00)00463-7
(2000)Doi:10.1016/j.tetlet.2007.11.192
(2008)
