SYNTHESIS OF (+/-)-2'-OXA-CARBOCYCLIC-2',3'-DIDEOXYNUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS

DOI: 10.1016/0040-4039(91)80873-5

Source and publish data:

Tetrahedron Letters p. 271 - 274 (1991)

Update date:2022-07-30

Topics:

Authors:

Bamford, Mark J.

Humber, David C.

Storer, Richard

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Article abstract of DOI:10.1016/0040-4039(91)80873-5

Novel 2',3'-dideoxynucleosides, having the pentofuranosyl oxygen at the 2'-position, were obtained by a short synthetic route from diethyl malonate and bromoacetalehyde dimethyl acetal.The results of biological testing against HIV-1 in vitro are presented.

Full text of DOI:10.1016/0040-4039(91)80873-5

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