ω-alkanoic Acids: From Specific LTA4 Hydrolase Inhibitors to LTB4 Receptor Antagonists

DOI: 10.1021/jm00095a011

Source and publish data:

Journal of Medicinal Chemistry p. 3170 - 3179 (1992)

Update date:2022-08-04

Topics: thienyl alkanoic acid

Authors:

Labaudiniere, Richard

Hilboll, Gerd

Leon-Lomeli, Alicia

Terlain, Bernard

Cavy, Francoise

et al. et al.

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Article abstract of DOI:10.1021/jm00095a011

A series of ω-<(ω-arylalkyl)thienyl>alkanoic acid isomers was prepared and a structure-activity relationship was investigated.These compounds have displayed either LTA4 hydrolase inhibition activities or LTB4 receptor binding activities, or both, dependin

Full text of DOI:10.1021/jm00095a011

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