Inversion of the configuration of cyanohydrins by a Mitsunobu esterification reaction

DOI: 10.1016/S0040-4020(01)86287-6

Source and publish data:

Tetrahedron p. 1063 - 1070 (1993)

Update date:2022-08-03

Topics:

Authors:

Warmerdam, Erwin G. J. C.

Brussee, Johannes

Kruse, Chris G.

Van Der Gen, Arne

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Article abstract of DOI:10.1016/S0040-4020(01)86287-6

Optically active (R)-cyanohydrins have been transformed into cyanohydrin esters of opposite configuration under Mitsunobu conditions and subsequently solvolyzed to (S)-cyanohydrins in high chemical and optical yield. The method works well for allylic and

Full text of DOI:10.1016/S0040-4020(01)86287-6

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