Studies on the chemistry of rapamycin: Novel transformations under Lewis-acid catalysis

DOI: 10.1016/S0040-4039(00)77473-9

Source and publish data:

Tetrahedron Letters p. 991 - 994 (1993)

Update date:2022-08-03

Topics:

Authors:

Luengo Luengo

Konialian

Holt Holt

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Article abstract of DOI:10.1016/S0040-4039(00)77473-9

The reactivity of rapamycin under mild Lewis-acid catalysis has been investigated. The molecule has been found to be extremely sensitive to basic reagents due to carboxylate elimination β to the C₂₄ ketone. However, transformations normally eff

Full text of DOI:10.1016/S0040-4039(00)77473-9

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