A highly diastereoselective aldol reaction of dicobalt hexacarbonyl propynal complex and uncomplexed propynal: A stereoselective divergent synthesis of (±)-PS-5 and (±)-6-Epi-PS-5

Article abstract of DOI:10.1016/0040-4039(91)80532-B

The aldol reaction of cobalt complexed propynal 1 with O-silyl ketene O,S-acetals 3 gave the syn-products exclusively, while the uncomplexed propynal 2, the corresponding anti-compounds. A successful application of these stereoselective reactions to a syn