Enzyme-catalyzed synthesis of optically pure β-sulfonamidopropionic acids. Useful starting materials for P-3 site modified renin inhibitors

Article abstract of DOI:10.1016/0040-4039(93)85095-E

The novel and efficient of several racemic β-sulfonamidopropionate esters is described. Treatment of the racemic esters with Chymotrypsin or Subtilisin Carlsberg (purified of detergent grade) provided the corresponding (S)-carboxylic acids in 60-90% yield