Synthesis p. 334 - 342 (1993)
Update date:2022-07-29
Topics:
Coates
McKillop
A one-pot process for the preparation of 6-phenyl-3(2H)-pyridazinone from acetophenone and glyoxylic acid has been investigated and shown to have wide utility in the preparation of 6- and 5,6-substituted 3(2H)-pyridazinones. Limitations to the process encountered with 2'-hydroxyacetophenone and with basic hetero-aromatic ketones have been overcome, and the processes described offer the rapid and efficient synthesis of many 6-substituted pyridazinones from readily available ketones.
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Doi:10.1021/ja01607a064
(1955)Doi:10.1016/S0040-4039(00)60792-X
(1993)Doi:10.1016/S0040-4020(01)80717-1
(1991)Doi:10.1021/om200492f
(2011)Doi:10.1007/BF00480879
(1990)Doi:10.1039/c1ob05440f
(2011)