Nucleophilic Aromatic Substitution on 1-Alkoxy-2-naphthoates with 1-Naphthyl Grignard Reagents. A Practical and Convenient Asymmetric Synthesis of 1,1'-Binaphthyl-2-carboxylates

DOI: 10.1246/bcsj.66.613

Source and publish data:

Bulletin of the Chemical Society of Japan p. 613 - 622 (1993)

Update date:2022-09-26

Topics:

Authors:

Hattori, Tetsutaro

Hotta, Hiroki

Suzuki, Takatsugu

Miyano, Sotaro

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Article abstract of DOI:10.1246/bcsj.66.613

1-Naphthyl Grignard reagents efficiently displace the 1-alkoxyl group of 1-alkoxy-2-naphthoic esters to provide an easy access to the corresponding 1,1'-binaphthyl-2-carboxylates in excellent yields; isopropyl ester is bulky enough to prevent the Grignard

Full text of DOI:10.1246/bcsj.66.613

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