Nucleophilic Aromatic Substitution on 1-Alkoxy-2-naphthoates with 1-Naphthyl Grignard Reagents. A Practical and Convenient Asymmetric Synthesis of 1,1'-Binaphthyl-2-carboxylates

Article abstract of DOI:10.1246/bcsj.66.613

1-Naphthyl Grignard reagents efficiently displace the 1-alkoxyl group of 1-alkoxy-2-naphthoic esters to provide an easy access to the corresponding 1,1'-binaphthyl-2-carboxylates in excellent yields; isopropyl ester is bulky enough to prevent the Grignard