Design and modeling of new platelet-activating factor antagonists. 1. Synthesis and biological activity of 1,4-bis(3',4',5'-trimethoxybenzoyl)-2- [[(substituted carbonyl and carbamoyl)oxy]methyl]piperazines

DOI: 10.1021/jm00060a006

Source and publish data:

Journal of Medicinal Chemistry p. 990 - 1000 (1993)

Update date:2022-08-04

Topics:

Authors:

Lamouri Lamouri

Heymans Heymans

Tavet Tavet

Dive Dive

Batt Batt

Blavet Blavet

Braquet Braquet

Godfroid

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Article abstract of DOI:10.1021/jm00060a006

To further investigate our hypothesis on the structure of the platelet- activating factor (PAF) receptor, 35 compounds derived from 1,4-bis(3',4',5'- trimethoxybenzoyl)piperazine were synthesized and their in vitro antagonistic effect was measured. Substi

Full text of DOI:10.1021/jm00060a006

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