Design and modeling of new platelet-activating factor antagonists. 1. Synthesis and biological activity of 1,4-bis(3',4',5'-trimethoxybenzoyl)-2- [[(substituted carbonyl and carbamoyl)oxy]methyl]piperazines

Article abstract of DOI:10.1021/jm00060a006

To further investigate our hypothesis on the structure of the platelet- activating factor (PAF) receptor, 35 compounds derived from 1,4-bis(3',4',5'- trimethoxybenzoyl)piperazine were synthesized and their in vitro antagonistic effect was measured. Substi