Peptide modification by incorporation of α-trifluoromethyl α-amino acids via trifluoromethyl-substituted acylimines

Article abstract of DOI:10.1016/S0022-1139(00)80427-3

α-Trifluoromethyl-substituted α-amino acids can be introduced into the C-terminal position of peptides via acylimines obtained on reaction of trifluoropyruvates with N-protected α-amino acid amides and dipeptide amides, respectively.