Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b

Article abstract of DOI:10.1016/j.bmc.2004.09.019

Three types of mono- and disaccharides as well as some chaetomellic acid A analogs were synthesized and evaluated for inhibitory activity against the E. coli transglycosylase PBP1b. Three types of mono- and disaccharides 3a,b, 4a-c, 5, and some chaetomell