
Tetrahedron Letters p. 8675 - 8678 (1997)
Update date:2022-08-03
Topics:
Smith III, Amos B.
Lin, Qiyan
Nakayama, Kiyoshi
Boldi, Armen M.
Brook, Christopher S.
McBriar, Mark D.
Moser, William H.
Sobukawa, Masao
Zhuang, Linghang
A convergent synthesis of the C(1-17) AB-ring subunit of the spongistatins, exceedingly scarce and highly antimitotic polyether macrolides, has been achieved via a one-flask dithiane bisalkylation, stereocontrolled spiroketalization, and Julia sulfone coupling/methylenation.
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