Silver-Catalyzed C(sp2)-H Functionalization/C-O Cyclization Reaction at Room Temperature

Article abstract of DOI:10.1021/jo5024238

Silver-catalyzed C(sp²)-H functionalization/C-O cyclization has been developed. The scalable reaction proceeds at room temperature in an open flask. The present method exhibits good functional-group compatibility because of the mild reaction conditions. Using a AgNO₃ catalyst and a (NH₄)₂S₂O₈ oxidant in CH₂Cl₂/H₂O solvent, various lactones are obtained in good to excellent yields. A kinetic isotope effect (KIE) study indicates that the reaction may occur via a radical process.