Synthesis of 2'-deoxyuridine and 5-fluoro-2'-deoxyuridine derivatives and evaluation in antibody targeting studies

DOI: 10.1021/jm00063a007

Source and publish data:

Journal of Medicinal Chemistry p. 1570 - 1579 (1993)

Update date:2022-08-03

Topics:

Authors:

Henn Henn

Garnett Garnett

Chhabra Chhabra

Bycroft Bycroft

Baldwin Baldwin

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Article abstract of DOI:10.1021/jm00063a007

Derivatives of 2'-deoxyuridine and of the anticancer agent 5-fluoro-2'- deoxyuridine (FdUR) were linked indirectly via a human serum albumin carrier (HSA) to the murine antiosteosarcoma monoclonal antibody 791T/36. Starting from the 2'-deoxyuridines 1a an

Full text of DOI:10.1021/jm00063a007

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