
Synlett p. 959 - 961 (1997)
Update date:2022-08-04
Topics:
Cacchi, Sandro
Fabrizi, Giancarlo
Carangio, Antonella
Functionalised pyrazoles have been prepared in good overall yield through a facile one-pot procedure. The synthesis includes the palladium-catalysed coupling of the readily available N-tosyl-N-propargylhydrazine with aryl iodides or vinyl triflates, the palladium-catalysed annulation of the resulting N-tosyl-N-(1-aryl/vinyl-1-propyn3-yl)hydrazine and exposure of the reaction mixture arising from the annulation step to KOBut.
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