Conformational effects on retinoid receptor selectivity. 1. Effect of 9- double bond geometry on retinoid X receptor activity

Article abstract of DOI:10.1021/jm00070a003

A major challenge is the development of retinoids with selective biological activities. Recently, studies on retinoid response mechanisms indicate that retinoids activate two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the