Organic Letters p. 4767 - 4770 (2019)
Update date:2022-08-04
Topics:
Okabe, Hiroyuki
Naraoka, Asuka
Isogawa, Takahiro
Oishi, Shunsuke
Naka, Hiroshi
Palladium-catalyzed dehydration of primary amides to nitriles efficiently proceeds under mild, aqueous conditions via the use of dichloroacetonitrile as a water acceptor. A key to the design of this transfer dehydration catalysis is the identification of an efficient water acceptor, dichloroacetonitrile, that preferentially reacts with amides over other polar functional groups with the aid of the Pd catalyst and makes the desired scheme exergonic, thereby driving the dehydration.
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