Amesergide and structurally related nor-D-ergolines: 5HT2 receptor interactions in the rat

Article abstract of DOI:10.1021/jm00070a011

A series of tricyclic (nor-D) partial ergolines were synthesized via a highly convergent enantiospecific strategy, ultimately arising from a racemic tricyclic ketone. Michael addition to an acrylamide, followed by reductive methylation, afforded the key i