Bioorganic and Medicinal Chemistry Letters p. 2223 - 2228 (1997)
Update date:2022-08-04
Topics:
Neidhart, Werner
Breu, Volker
Burri, Kaspar
Clozel, Martine
Hirth, Georges
Klinkhammer, Uwe
Giller, Thomas
Ramuz, Henri
Implementation of a pyridylcarbamoyl group and an isopropylpyridylsulfonamide substituent as key components in the scaffold of Bosentan resulted in the identification of the potent orally active endothelin receptor antagonist Ro 48-5695. It shows affinities for ET(A) and ET(B) receptors in the low nanomolar range and high functional antagonistic potency in vitro.
View MoreZibo Linzi Darong Fine Chemical Co., Ltd(expird)
Contact:86-532-67773200; 15689126900
Address:Qidu town,Linzi district,Zibo city,Shandong province,China
Shanghai KFSL Pharmaceutical Technology Co.,Ltd.
Contact:+86-21-39971718
Address:859 jiadingchengliu shanghai
website:http://www.tbbmed.com
Contact:86--21-50498136
Address:Room 6002, Building 7-1, No.160 Basheng Road,Pudong Area,Shanghai China
website:http://www.sjc.com.tw
Contact:(886) 2-2396-6223
Address:14Fl., No. 99. Sec. 2, Jen Ai Road
Zhejiang Kente Chemical Co.,Ltd.
Contact:86-0576-87651912
Address:No.7, Fengxi West Road, Modern Industrial Zone
Doi:10.1016/j.tetlet.2013.09.099
(2013)Doi:10.1016/00404-0399(50)14024-
(1995)Doi:10.1021/acs.jmedchem.1c00318
(2021)Doi:10.1016/0040-4020(94)00969-2
(1995)Doi:10.1134/S1070428013110122
()Doi:10.1016/j.molcata.2013.10.016
(2014)
