Solid phase synthesis of phosphinic peptides

DOI: 10.1016/S0040-4039(00)60522-1

Source and publish data:

Tetrahedron Letters p. 4181 - 4184 (1993)

Update date:2022-08-04

Topics:

Authors:

Campagne, Jean-Marc

Coste, Jacques

Guillou, Laurent

Heitz, Annie

Jouin, Patrick

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Article abstract of DOI:10.1016/S0040-4039(00)60522-1

The absence of a coupling reaction between a phosphinic acid and an amino ester during activation with the reagents BOP or PyBOP allowed the synthesis of phosphinopeptides from phospho-analogues of dipeptides, unprotected on the phosphinic acid.

Full text of DOI:10.1016/S0040-4039(00)60522-1

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Product name:3-[(1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionic acid methyl ester

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