First asymmetric @Synthesis of carnosadine

Article abstract of DOI:10.1016/S0040-4020(01)80152-6

The first asymmetric synthesis of the naturally-occurring cyclopropane amino acid carnosadine, 1, has been carried out. Starting from the previously available chiral intermediate 2, appropriate amine protection and side-chain modifications permitted introduction of the key guanidyl substituent in a short and efficient synthesis to give the title compound in five steps and 45% overall yield.