Tetrahedron p. 6375 - 6380 (1993)
Update date:2022-07-30
Topics:
Aitken, David J.
Guillaume, Dominique
Husson, Henri-Philippe
The first asymmetric synthesis of the naturally-occurring cyclopropane amino acid carnosadine, 1, has been carried out. Starting from the previously available chiral intermediate 2, appropriate amine protection and side-chain modifications permitted introduction of the key guanidyl substituent in a short and efficient synthesis to give the title compound in five steps and 45% overall yield.
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(2014)Doi:10.1021/jo00075a065
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(2014)
