Synthesis of (α,α-Difluoroalkyl)phosphonates by Displacement of Primary Triflates

DOI: 10.1021/jo00075a005

Source and publish data:

Journal of Organic Chemistry p. 6174 - 6176 (1993)

Update date:2022-09-26

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Authors:

Berkowitz, David B.

Eggen, MariJean

Shen, Quanrong

Sloss, Darby G.

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Article abstract of DOI:10.1021/jo00075a005

Simple primary alkyl triflates and those derived from several monosaccharides are cleanly displaced by diethyl(lithiodifluoromethyl)phosphonate to provide the corresponding (α,α-difluoroalkyl)phosphonates in minutes at -78 deg C.

Full text of DOI:10.1021/jo00075a005

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