Tetrahedron Asymmetry p. 1435 - 1438 (1993)
Update date:2022-08-04
Topics:
Hamon, David P. G.
Massy-Westropp, Ralph A.
Newton, Josephine L.
(S)-2-<4'-(2''-Methylpropyl)phenyl>propanoic acid (ibuprofen) and (S)-2-(3'-benzoylphenyl)propanoic acid (ketoprofen) have been synthesised in high enantiomeric excess.Control of the stereochemistry was achieved by a combination of Sharpless epoxidation followed by catalytic hydrogenolysis of the introduced benzylic epoxide oxygen bond.
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Doi:10.1016/S0040-4039(00)60532-4
(1993)Doi:10.1002/adsc.201900406
(2019)Doi:10.1080/00397919308011269
(1993)Doi:10.1016/S0014-827X(00)00002-1
(2000)Doi:10.1016/S0040-4020(01)89176-6
(1989)Doi:10.1039/P29930000923
(1993)
