Chiral precursors for the synthesis of enantiomerically pure piperidines. Total synthesis of (R)-(-)-coniine

Article abstract of DOI:10.1016/S0040-4039(00)76803-1

The preparation of chiral cis- and trans-oxazolopiperidones 1, 2, and 3 by alternative procedures and an efficient synthesis of the piperidine alkaloid (R)-(-)-coniine from trans-1 is reported.