First Metalation of Aryl Iodides: Directed Ortho-Lithiation of Iodopyridines, Halogen-Dance, and Application to Synthesis

DOI: 10.1021/jo00079a031

Source and publish data:

Journal of Organic Chemistry p. 7832 - 7838 (1993)

Update date:2022-09-26

Topics:

Authors:

Rocca, P.

Cochennec, C.

Marsais, F.

Thomas-dit-Dumont, L.

Mallet, M.

et al. et al.

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Article abstract of DOI:10.1021/jo00079a031

Metalation of iodopyridines was succesfully achieved by LDA at low temperature.In many cases, lithiation is ortho directed by the iodo group which subsequently ortho-migrates very fast to give stabilized iodolithiopyridines.This procedure was applied to 2

Full text of DOI:10.1021/jo00079a031

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