A new synthetic route for the γ-lactone precursors of hydroxyethylene dipeptide isosteres

Article abstract of DOI:10.1016/S0040-4039(00)73819-6

δ-Phthalimido-γ-ketoesters were obtained by the Pd catalyzed coupling reaction between acid chlorides and organozinc reagents derived from β-iodoesters, and were converted into the γ-lactones precursors of Phe-ψ[H.E.]-Ala and Phe-ψ[H.E.]-Pro (15a,b-18a,b).