A new synthetic route for the γ-lactone precursors of hydroxyethylene dipeptide isosteres

DOI: 10.1016/S0040-4039(00)73819-6

Source and publish data:

Tetrahedron Letters p. 5939 - 5942 (1993)

Update date:2022-08-05

Topics:

Authors:

Sakurai Sakurai

Hata Hata

Yabe Yabe

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Article abstract of DOI:10.1016/S0040-4039(00)73819-6

δ-Phthalimido-γ-ketoesters were obtained by the Pd catalyzed coupling reaction between acid chlorides and organozinc reagents derived from β-iodoesters, and were converted into the γ-lactones precursors of Phe-ψ[H.E.]-Ala and Phe-ψ[H.E.]-Pro (15a,b-18a,b).

Full text of DOI:10.1016/S0040-4039(00)73819-6

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