Pyrimidinones as reversible metaphase arresting agents

Article abstract of DOI:10.1016/0223-5234(93)90014-6

5-Halo-N(1)-substituted 2(1H)-pyrimidinones have the ability to cause reversible arrest of mitosis during metaphase.Highly active compounds have a heteroatom (O, S or N) in the β-position of the N(1)-carbon chain which is further substituted by an aryl gr