Synthesis of 4,4-Difluoro-L-Arginine

DOI: 10.1016/S0040-4039(00)79285-9

Source and publish data:

Tetrahedron Letters p. 7195 - 7196 (1993)

Update date:2022-08-05

Topics:

Authors:

Kim, Kyoung Soon

Qian, Ligang

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Article abstract of DOI:10.1016/S0040-4039(00)79285-9

Preparation of 4,4-difluoro-L-arginine 1 as an L-arginine surrogate is described starting with tBoc-D-serine. pKa of guanidine moiety of 1 was found to be 11.2 compared to 13.2 of arginine guanidine group.

Full text of DOI:10.1016/S0040-4039(00)79285-9

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