Archiv der Pharmazie p. 437 - 441 (1993)
Update date:2022-07-30
Topics:
Schwenkkraus
Otto
Alkylation of the 3-chloroethyl substituted β-sultam 1 with bromoacetates yields the N- and 3-substituted β-sultams 2; exchange of halogens affords esters 3. Reactions of 1 or of the analogues 8 with isocyanates make the carbamoyl derivatives 5, 6, and 9 available. While cyclization of 6 with n-BuLi in the presence of HMPT yields the bicyclic β-sultams 7, the analogous reaction of 9 failed. The bicyclic β-sultams 12 and 14 are obtained from 3-hydroxyalkyl β-sultams 11 and 13 and carbonyl compounds. None of the prepared β-sultams showed any antibacterial activity.
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Doi:10.1080/07328319308016204
(1993)Doi:10.1002/ardp.19933261206
(1993)Doi:10.1039/c2cc31161e
(2012)Doi:10.1021/om00016a053
(1994)Doi:10.1016/j.tetasy.2013.11.012
(2014)Doi:10.1016/0223-5234(93)90087-U
(1993)