New phosphitylating reagent in the nucleotide chemistry containing two 4-nitrophenoxy leaving groups. Remarkably fast and clean phosphitylations activated by DBU leading to thio- and seleno-oligonucleotides

DOI: 10.1016/0040-4039(93)85068-8

Source and publish data:

Tetrahedron Letters p. 6451 - 6454 (1993)

Update date:2022-07-31

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Authors:

Helinski, Jan

Dabkowski, Wojciech

Michalski, Jan

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Article abstract of DOI:10.1016/0040-4039(93)85068-8

A new synthetic approach to modified oligonucleotides based on N,N′-diisopropyl-di-(4-nitrophenyl)phosphoroamidite 1 is described. The procedure involves displacement of either 4-nitrophenoxy or diisopropylamino ligands. The former proceeds very fast in t

Full text of DOI:10.1016/0040-4039(93)85068-8

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Product name:O-[5'-O-(4,4-dimethoxytrityl)thymidin-3-yl]-O-[3'-O-(4,4-dimethoxytrityl)thymidin-5'-yl]N,N-diisopropylphosphoramidite

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