Asymmetric synthesis of α-keto β-lactams via [2+2] cycloaddition reaction: A concise approach to optically active α-hydroxy β-lactams and β-alkyl(aryl)isoserines

DOI: 10.1016/S0040-4039(00)73743-9

Source and publish data:

Tetrahedron Letters p. 6325 - 6328 (1993)

Update date:2022-09-26

Topics:

Authors:

Palomo Palomo

Aizpurua

Miranda Miranda

Mielgo Mielgo

Odriozola

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Article abstract of DOI:10.1016/S0040-4039(00)73743-9

The cycloaddition reaction of the Evans-Sjogren ketenes to imines, followed by α-hydroxylation of the resulting cycloadducts provides an efficient general asymmetric synthesis of α-keto β-lactams and derivatives.

Full text of DOI:10.1016/S0040-4039(00)73743-9

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