Conjugate Addition of Amines and Thiols to (R)-1-Acetyl-5-isopropoxy-3-pyrrolin-2-one; Preparation of Enantiopure N-Acyliminium Ion Precursors

DOI: 10.1016/S0957-4166(00)80435-8

Source and publish data:

Tetrahedron Asymmetry p. 1941 - 1948 (1993)

Update date:2022-08-04

Topics: Amines Conjugate addition Thiols Precursors Enantiopure N-Acyliminium Ion

Authors:

Koot, Wim-Jan

Hiemstra, Henk

Speckamp, W. Nico

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Article abstract of DOI:10.1016/S0957-4166(00)80435-8

Conjugate addition reactions of amines and thiols to enantiopure (R)-1-acetyl-5-isopropoxy-3-pyrrolin-2-one are shown to proceed with high stereoselectivity.The benzylamine and the benzyl mercaptan adducts were N-deacylated and then treated with Lewis aci

Full text of DOI:10.1016/S0957-4166(00)80435-8

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