Synthesis of Benzo-Fused Benzodiazepines Employed as Probes of the Agonist Pharmacophore of Benzodiazepine Receptors

DOI: 10.1021/jm00032a007

Source and publish data:

Journal of Medicinal Chemistry p. 745 - 757 (1994)

Update date:2022-08-04

Topics:

Authors:

Zhang, Weijiang

Koehler, Konrad F.

Harris, Bradford

Skolnick, Phil

Cook, James M.

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Article abstract of DOI:10.1021/jm00032a007

The synthesis and in vitro evaluation of benzo-fused benzodiazepines 1-6 are described.These "molecular yardsticks" were employed to probe the spatial dimensions of the lipophilic pocket L₂ in the benzodiazepine receptor (BzR) cleft and to dete

Full text of DOI:10.1021/jm00032a007

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