Palladium-Catalyzed Carbonylative Cyclization of o-Allylbenzyl Halides To Produce Benzo-Annulated Enol Lactones and/or Bicyclohept-3-en-6-ones. An Efficient Route to U-68,215

Article abstract of DOI:10.1021/jo00023a011

Treatment of o-allylbenzyl halides with CO in the presence of 1.5-2.0 equiv of a base, such as NEt3, and a catalytic amount of a palladium complex, such as Cl2Pd(PPh3)2, provides a 2,3,3a,4-tetrahydro-2-oxonaphthyl<2,3-b>furans and/or cyclobutanone derivatives tentatively identified as 2,2a,7,7a-tetrahydro-1H-cyclobutinden-2-ones.