Synthesis, binding affinities and uterotrophic activity of some 2-substituted estradiol and ring-A-fused pyrone derivatives

Article abstract of DOI:10.1016/0223-5234(94)90122-8

A series of estradiol analogs has been synthesized and examined as potential estrogens.Nuclear modifications included a variety of substituents at the 2 position of estradiol, which was previously thought to be inhibitory for activity, and inclusion of th