Journal of the Chemical Society. Perkin transactions I p. 2107 - 2110 (1993)
Update date:2022-07-30
Topics:
Lewis, Maureen
McMurry, T. Brian H.
Clercq, Erik De
5-Fluoro-4-tosyloxypentyl pivalate has been synthesized in four steps from 2-(fluoromethyl)tetrahydrofuran.Condensation with 2-amino-6-chloropurine gave the N-9 derivative, which was converted via the 6-methoxy analogue into 9-(1-fluoro-5-hydroxypentan-2-yl)-9H-guanine.The latter was evaluated, and found inactive, in a large variety of antiviral assays.
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