Evaluation of a Vitamin-Cloaking Strategy for Oligopeptide Therapeutics: Biotinylated HIV-1 Protease Inhibitors

DOI: 10.1021/jm00028a013

Source and publish data:

Journal of Medicinal Chemistry p. 293 - 304 (1994)

Update date:2022-07-30

Topics:

Authors:

Islam, Imadul

Ng, Ka-yun

Chong, Kong Teck

McQuade, Thomas J.

Hui, John O.

et al. et al.

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Article abstract of DOI:10.1021/jm00028a013

The outstanding limitations to the oligopeptide as a therapeutic agent are poor oral availability and rapid biliary clearance.To address these concerns a series of eight peptidic HIV-1 protease inhibitors containing the structural segment of the vitamin b

Full text of DOI:10.1021/jm00028a013

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