Synthesis and Biological Evaluation of 5-methylene>oxazoles, -thiazoles, and -imidazoles: Novel Dual 5-Lipoxygenase and Cyclooxygenase Inhibitors with Antiinflammatory Activity

DOI: 10.1021/jm00028a017

Source and publish data:

Journal of Medicinal Chemistry p. 322 - 328 (1994)

Update date:2022-07-29

Topics:

Authors:

Unangst, Paul C.

Connor, David T.

Cetenko, Wiaczeslaw A.

Sorenson, Roderick J.

Kostlan, Catherine R.

et al. et al.

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Article abstract of DOI:10.1021/jm00028a017

A variety of benzylideneoxazoles, -thiazoles, and -imidazoles derived from 2,6-di-tert-butylphenol were prepared and evaluated as dual inhibitors of 5-lipoxygenase and cyclooxygenase in rat basophilic leukemia (RBL-1) cells.The target compounds exhibit va

Full text of DOI:10.1021/jm00028a017

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