Synthesis and Biological Evaluation of 5-methylene>oxazoles, -thiazoles, and -imidazoles: Novel Dual 5-Lipoxygenase and Cyclooxygenase Inhibitors with Antiinflammatory Activity

DOI: 10.1021/jm00028a017

Source and publish data:

Journal of Medicinal Chemistry p. 322 - 328 (1994)

Update date:2022-07-29

Topics:

Authors:

Unangst, Paul C.

Connor, David T.

Cetenko, Wiaczeslaw A.

Sorenson, Roderick J.

Kostlan, Catherine R.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00028a017

A variety of benzylideneoxazoles, -thiazoles, and -imidazoles derived from 2,6-di-tert-butylphenol were prepared and evaluated as dual inhibitors of 5-lipoxygenase and cyclooxygenase in rat basophilic leukemia (RBL-1) cells.The target compounds exhibit va

Full text of DOI:10.1021/jm00028a017

Products guided by the article

Product name:(Z)-5-<<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl>methylene>-1-methyl-2-thioxo-4-imidazolidinone

Cas No:154052-53-6

R&D Labs maybe for 154052-53-6

Jewim Pharmaceutical (Shandong) Co., Ltd

Contact:+8615621883869

Address:山东省泰安市高新技术产业开发区配天门大街西首
ZCIC INTERNATIONAL LTD

Contact:+86-512-56795332

Address:No227 Shuanglong Rd, Fenghuang, Zhangjiagang
Shanghai Balmxy Pharmaceutical Co., Ltd

Contact:0086-21-24206007

Address:Room 402, 15#, No. 909 wangyue Road, shanghai, P. R. China
Wuhan HengHeDa Pharm Co., Ltd

Contact:86-27-84888681

Address:Wuhan economic & technology development zone
Changzhou Screw International Trading Co., Ltd.

Contact:13906149256,18001495888

Address:Jiangsu，Jintanqu

Relevant to this article

(1R,5R,8S,9S)-deoxyloganic acid from Nepeta cataria

Doi:10.1248/cpb.32.2809
(1984)
Iridium(III)-Catalyzed Directed ortho-C(sp²)–H Amidation of Arenes with Sulfonamides

Doi:10.1002/ejoc.201800192
(2018)
A convergent stereocontrolled synthesis of [3-¹⁴C]solanesol

Doi:10.1002/jlcr.3083
(2013)
Two New Routes to the C19-C26 Tetrahydrofuran Fragment of the Acyl Tetronic Acid Ionophore Tetronasin (ICI M139603)

Doi:10.1016/S0040-4039(00)76542-7
(1994)
Chromium(II)-Mediated Nickel(II)-Catalysed Cyclisations of (Iodoaryl)-Substituted Alkynes and Alkynals

Doi:10.1016/S0040-4039(00)76769-4
(1994)
The preparation of novel thiophene-based macrocyclic Mannich bases

Doi:10.1039/b007661i
(2001)

Article Doi