Asymmetric synthesis. XXX. Synthesis of 3-substituted piperidines from chiral non-racemic lactams

Article abstract of DOI:10.1016/S0040-4039(00)77162-0

A series of 3-substituted piperidines in enantiomerically pure form has been synthesized from lactam 3 by a stereospecific route involving a postulated rigid amide enolate. This strategy has been applied to the synthesis of (+)-stenusine 10.