Chemical and Pharmaceutical Bulletin p. 1910 - 1919 (1993)
Update date:2022-09-26
Topics:
Murakami
Watanabe
Yokoyama
Naomachi
Iwase
Watanabe
Morihata
Okuyama
Kamakura
Takahashi
Atoda
Tojo
Morita
Ishii
Various kinds of ethyl pyruvate 2-(2-substituted phenyl)hydrazones (1) were subjected to Fischer indolization with acid catalysts. All the phenylhydrazones gave corresponding normal 7-substituted indoles (2). In addition, phenylhydrazones whose ortho-substituent is electron-donative or has a central atom with an unshared electron pair tended to give the 4- or 5- substituted indole (3), which was produced by migration of the ortho- substituent during cyclization, whereas those whose ortho-substituent is electron-attractive tended to give little or no such abnormal product. The kind of acid catalyst used had some effect on the yield ratio of products but not on the kind of products.
View MoreWuhan Yitongtai Science and Technology Co.,Ltd.
Contact:+86-27-88933550
Address:27th Fl. Bldg. 1, Shuian International Mansion, Heping Ave, Wuhan, Hubei, China
shanghai tuomiao chemicial co.,ltd.
website:https://www.tuomiaochem.com/
Contact:021 - 59853336
Address:shanghai
Quhua Zhongxing Refrigeration Technology Co.,Ltd.
Contact:+86-5708886618
Address:318 Bulding 2, No.866 Quhua Rd.,Kecheng District
MTT Pharma & Bio-technology Co.,Ltd(expird)
Contact:+86-21-58407925
Address:Room2019, Building C, Tomson Center, No.158, Zhang Yang Road, Shanghai, China
website:http://www.lonwinchem.com
Contact:Tel: 86-21-59858395
Address:No#966,Huaxu Road,Shanghai 201702,P.R.China
Doi:10.1248/cpb.58.160
(2010)Doi:10.1021/ja102758v
(2010)Doi:10.1016/j.tetlet.2010.07.088
(2010)Doi:10.1039/c0nj00158a
(2010)Doi:10.1039/c004960c
(2010)Doi:10.3390/ph12040159
(2019)
