A convenient synthesis of S-cyanoethyl-protected 4-thiouridine and its incorporation into oligoribonucleotides

DOI: 10.1016/S0040-4039(00)75812-6

Source and publish data:

Tetrahedron Letters p. 765 - 768 (1994)

Update date:2022-08-03

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Authors:

Adams, Chris J.

Murray, James B.

Arnold, John R. P.

Stockley, Peter G.

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Article abstract of DOI:10.1016/S0040-4039(00)75812-6

A reliable preparation of S⁴-cyanoethyl-4-thiouridine and its incorporation into oligoribonucleotides is reported. Deprotection of oligoribonucleotides with DBU in acetonitrile followed by methanolic ammonia allows the use of standard N-benzyl

Full text of DOI:10.1016/S0040-4039(00)75812-6

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