Journal of Medicinal Chemistry p. 11148 - 11160 (2016)
Update date:2022-08-05
Topics: binding affinity X-ray crystallography High-Throughput Screening Structure-Activity Relationship (SAR) Small molecules HIV-1
Abulwerdi, Fardokht A.
Shortridge, Matthew D.
Sztuba-Solinska, Joanna
Wilson, Robert
Le Grice, Stuart F.J.
Varani, Gabriele
Schneekloth, John S.
Small molecules that bind to RNA potently and specifically are relatively rare. The study of molecules that bind to the HIV-1 transactivation response (TAR) hairpin, a cis-acting HIV genomic element, has long been an important model system for the chemist
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