
Tetrahedron p. 9735 - 9750 (1993)
Update date:2022-08-04
Topics:
Nakajima
Tomioka
Koga
Novel chiral pyrrolidine-based diamines with C2-symmetry 2, 3 and their related compounds 4-8 were designed and synthesized in optically pure forms. Both (+)- and (-)-2 were prepared from optical active ditosylate 9. 3 was prepared from 3,5-dimethylbenzaldehyde through optical resolution and its absolute stereochemistry was correlated with 2,3-dimethylsuccinate 27. 4 was prepared from (-)-diol 28. 5-8 were prepared from 9 and 11.
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Doi:10.1021/jo971907r
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